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A body of cues is known about how these mechanical stimuli affect cell morphology, proliferation, and differentiation.
While conceptually similar to the vulnerable window for electrical stimulation, there is a principally relevant difference in that mechanical stimuli affect cardiac tissue in a localized fashion.
The growing number of evidence has demonstrated the role of both biochemical and biomechanical signals in regulating MSC lineage-specific differentiation, where mechanical stimuli affect the metabolism of bone cells and their precursors.
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This is particularly true if a mechanical stimulus affects, both, cells that have regained excitability (these may depolarize, giving rise to ectopic foci, thus providing a trigger for arrhythmogenesis), and cells at more positive membrane potentials (whose repolarization time-course is altered, potentially furnishing an arrhythmia-sustaining substrate).
Also the timing of the mechanical stimuli could affect our results.
Diverse stimuli affect elongation of cells during angiogenesis, including growth factors, mechanical stretch and adjacent cells [ 22, 52, 53].
Although the mechanisms underlying postprandial fullness remain unclear, we speculate that some mechanical or chemical stimuli affecting intestinal wall (duodenum and/or small intestine) may play critical roles in causing the sensation of postprandial fullness.
Each of the stimuli affect the fabric in different ways.
However, whether mechanical stimulus can also affect Na+cyt loads that should be inherently linked to Ca2+cyt changes has not been determined yet.
We analysed the resulting differentially expressed gene sets using Gene Ontology annotations to identify significant enrichment of genes associated with particular biological processes, showing that removal of mechanical stimuli from muscle contractions affected genes associated with development and differentiation, cytoskeletal architecture and cell signalling.
In this work we used computational modelling to demonstrate how rigid immobilisation would affect the mechanical stimuli generated in the developing knee joint and we investigated the impact of such immobilisation on the tissues of the developing joint at morphological and molecular levels.
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