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Our results suggest that manipulating the VOCC and attenuating the opening of the calcium channels may be an effective technique to amplify matrix production via mechanical stimulation which may be applied to bone tissue engineering and potentially engineering of other load-bearing connective tissues.
At Aberystwyth it is hypothesised that high wind speeds caused mechanical stimulation which increased investment below ground to anchor the crop.
Solitary astrocytes are known to respond to mechanical stimulation, which does not compromise the plasma membrane integrity, by increasing their intracellular Ca2+ levels (Hua et al., 2004).
One such key environmental regulator of periarticular bone is mechanical stimulation, which, according to Wolff's law, is a key determinant of bone properties.
It has been observed that cytoplasmic streaming in root hairs of a symrk-3 mutant did not resume after mechanical stimulation, which raised the possibility that the absence of calcium-spiking upon injection of calcium-sensitive dyes into mutant root hair cells was a pleiotropic effect of this increased touch sensitivity (Esseling et al., 2004; Miwa et al., 2006).
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It should be underscored that, in physiological conditions, the quality and intensity of mechanical stimulation to which the endothelium is exposed depend on the vascular district.
The IHC transduces mechanical vibration into neural stimulation which is sent to the brain for interpretation.
Both mechanical strain and electrical stimulation, which increase the levels of intracellular ROS, also increase the proportion of beating cardiomyocytes within an EB population [72,94,95].
Chondrocytes have receptors for responding to mechanical stimulation, many of which are also receptors for ECM components [ 101].
Apart from mechanical strength, CNMs also provide electrical stimulation, which can be used for nerve tissue engineering.
These data suggest that intrathecal sandostatin significantly relieved thermal hyperalgesia behaviorally but with limited effects and dose-dependently reduced spinal Fos-LI neurons expression evoked by stroking stimulation, which may reflect mechanical allodynia in rats with sciatic constriction injury.
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