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Here, we developed an innovative system capable of applying precise uni- or biaxial mechanical stimulation to developing cartilage neotissues in a tightly controlled and automated fashion.
Here, we developed a user-friendly bioreactor system capable of facilitating uni- or biaxial mechanical stimulation to cartilage neotissues in an automated, well-controlled, and monitored fashion.
We also probed cellular response following compressive mechanical stimulation to PDMS substrates of varying stiffness.
These prototypes use mechanical stimulation to create these sensations, and electrical Peltier devices to generate different temperatures.
Chondrocytes in scaffolds have been shown to require mechanical stimulation to produce an extracellular matrix that resembles native cartilage.
In this study, we have implemented the aforementioned design considerations to develop an innovative bioreactor system capable of applying precise uni- or biaxial mechanical stimulation to developing cartilage neotissues in a tightly controlled and monitored environment.
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Mdx mice exhibit a reduced chondrogenic response to increased mechanical stimulation relative to controls.
The results of this study show mdx mice exhibit a reduced chondrogenic response to increased mechanical stimulation relative to controls.
Forms of tropism include phototropism (response to light), geotropism (response to gravity), chemotropism (response to particular substances), hydrotropism (response to water), thigmotropism (response to mechanical stimulation), traumatotropism (response to wound lesion), and galvanotropism, or electrotropism (response to electric current).
Collagen I immunofluorescence intensities were low within both free swelling and loaded constructs, but mechanical stimulation led to significantly higher levels compared to static controls (p = 0.023).
Because direct mechanical stimulation failed to activate MCs [7], most authors used indirect hypo-osmotic stimulation to explore their mechanosensory properties [22], [27].
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