Sentence examples for mechanical stimulation that from inspiring English sources

As a case study, the model is investigated to predict the cell density patterns of pre-osteoblasts MC3T3-e1 cells under a range of different loading regimes, to obtain an understanding of desirable mechanical stimulation that will enhance cell density distribution within TE scaffolds.

Finally, C. elegans exhibit a form of long-term memory in response to repetitive mechanical stimulation that requires GLR-1 [19]; we find that both GLR-2 and MAGI-1L mutants share a similar defect in long-term memory acquisition.

Specifically, we found that rapamycin blunted the heightened response to mechanical stimulation that develops around a site of injury and reduced the long-term mechanical hypersensitivity that follows partial peripheral nerve damage - a widely used model of chronic pain.

Secondary hyperalgesia is an increased sensitivity to noxious mechanical stimulation that develops in the uninjured area of the skin (areas unstimulated by capsaicin) and is thought to be a reflection of the increased response of spinal neurons (sensitisation) to A- nociceptor stimulation [36], [37].

The bone is then only localised at the outer rim, probably due to a lack of mechanical stimulation that is prerequisite for bone maintenance.

Administration of inflammatory soup into the paw results in hypersensitivity to osmotic and mechanical stimulation that is present in wild-type but not TRPV4-null mice.

Inhibition of the PKA-independent cAMP-mediators Epac1 and Epac2 with HJC0197 resulted in enhanced cartilage formation, which was additive to that of the mechanical stimulation, implying that the chondrogenesis-promoting effect of mechanical load was independent of Epac.

The same group demonstrated that normal and OA chondrocytes reacted differently to mechanical stimulation in that OA chondrocytes upregulated gene expression of the SP encoding gene, Tac1, whereas non-OA chondrocytes did not respond with changes in Tac1 gene expression [ 45].

Notably, it has been demonstrated that the cytoplasmic tail of γ-sarcoglycan is phosphorylated after mechanical stimulation, suggesting that it is a signalling sensor of contractility (Ref. 37).

These results support the hypothesis that both compressive strain and scaffold bioactivity have an important effect on the chondrocyte metabolic response to mechanical stimulation, and that the 3-D environment surrounding chondrocytes can actively participate in translating mechanical stimulation to the resident cells.

Interestingly, the expression of the hypertrophy marker COL10A1 was down-regulated following mechanical stimulation, indicating that loading may inhibit the partial ECM mineralization previously reported for GelMA-HAMA constructs29.