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Mechanotransduction — the mechanism by which a mechanical stimulation is transduced into a chemical signal — typically involves force-induced conformational changes in proteins or altered affinities to their binding partners but these interactions remain largely unexplored.
Mechanical stimulation is one of the alternative methods proposed to replace these chemical regulators.
A further consequence of mechanical stimulation is the induction of an oxidative burst and an increase in soluble sugar.
Central to understanding cellular response to mechanical stimulation is the organization of the cytoskeleton and its actin filament network.
The prediction of passive tissue response to mechanical stimulation is relevant to numerous fields of engineering and research.
Mechanical stimulation is a widely used method to enhance the formation and properties of tissue-engineered cartilage.
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In contrast, c-Fos, a gene indicative of mechanical stimulation, was upregulated in the marrow cells of mechanically stimulated explants, while the level of activated c-Jun decreased by 25%.
Further, molecular mechanisms underlying cellular responses to mechanical stimulation are not well understood.
The mechanisms by which bone senses and responds to mechanical stimulation are complex and occur at a number of hierarchical levels.
In addition, a separate nerve fiber class that was insensitive to mechanical stimulation was also recruited by bile.
Cells were held at −60 mV and mechanical stimulation was performed using a blunt glass probe (tip size 3 4 μm).
More suggestions(15)
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