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Early mechanical stiffness has been described in the rat CCl4 model of fibrosis.
Decreasing mechanical stiffness and increasing cell adhesivity were found to increase organoid yield.
Spatially-localized correlation of dGEMRIC-measured GAG distribution and mechanical stiffness in the human tibial plateau.
Swaminathan, V. et al. Mechanical Stiffness grades metastatic potential in patient tumor cells and in cancer cell lines.
In particular, mechanical stiffness and fluid transport are considered.
One such cue is the mechanical stiffness of a material.
Moreover, the organ-specific differentiation of stem cells was demonstrated to benefit a mechanical stiffness that mimics the one of the respective tissue54,55.
Physical parameters used in the present simulations are provided in Table 2. Aside from the geometry, which is known, there are only four key physical parameters: 1) fluid viscosity [41], [42], 2) the flexoelectric coefficient of lipid membranes [43] 3) the intracellular electrical conductance [37], and 4) the axial mechanical stiffness.
These results do not exclude the possibility that mechanical stiffness influences bone metastasis over a different range of elastic moduli.
These changes in matrix composition correlate with decreased mechanical stiffness.
Its structural alterations may lead to increased fragility and decreased mechanical stiffness, resulting in whole-cell mechanical vulnerability.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com