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TEMPOL treatment in old donors abolished the increases in aPWV and ex vivo intrinsic mechanical stiffness observed with transplantation into young recipient mice (Fig 2B,C) (both, P < 0.05).
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Two mechanical properties are investigated: the random distribution of the homogenised Young's modulus and the overall loss of stiffness observed in the case of extreme loading.
This trend in mechanical properties is preserved upon voltammetric cycling in both neutral and acidic media with marked increase in the stiffness observed in 0.4 M HClO4 for the PEDOT/dodecylsulfate case.
Mechanical stiffness and thermal property differences are also observed between the various layers in the film.
Importantly, these spreading and migration patterns were consistently observed on both rigid and compliant substrates, thus differences in ECM mechanical stiffness were not the underlying cause.
Collagen recruitment was observed to initiate at a finite strain, corresponding to a sharp increase in the measured mechanical stiffness, confirming the previous hypothesis and motivating the development of a new constitutive model to capture this response.
This observation is contrary to that found for mechanical stiffness, where tail cells were stiffer than head cells.
Features like chromatin compaction and mechanical stiffness of chromosomes influence the accessibility of the chromatin to the recombination machinery and as such these factors have been suggested to implement the interference between COs observed in most eukaryotes [ 32].
Furthermore, EMT has been observed at the edges of epithelial wounds [101, 124] and AFM studies have found that cell stiffness peaks approximately 10-20 μm from the wound edge with lower localized mechanical stiffness at the wound edge and far from the wound edge within the intact epithelial monolayer [125].
In particular, mechanical stiffness and fluid transport are considered.
One such cue is the mechanical stiffness of a material.
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