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A considerable improvement in the mechanical stiffness is indicated by AFM force measurements, being 9 times higher compared to the conventional three-beam actuator.
Considering the angular displacement range of the aforementioned normalized electromechanical moment colored in gray in Figure 2, the value of the electrostatic stiffness is negative, and the value of the mechanical stiffness is positive.
Despite the sealing achieved, regain of mechanical stiffness is limited to a maximum of 30% and only for crack mouth displacements up to 20 μm.
Mechanical stiffness is a fundamental parameter in the rational design of composites for bone tissue engineering in that it affects both the mechanical stability and the osteo-regeneration process at the fracture site.
In this paper, a new 3-DOF closed-chain planar parallel manipulator that meets certain requirements for optimal dynamic performance, kinematic and force manipulability, large usable workspace and high mechanical stiffness is proposed.
An additional example of cell behavior regulated by mechanical stiffness is cardiomyocyte commitment.
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This peak in mechanical stiffness was nullified with the expression of a dominant negative form of RhoA.
Scaffold dimensional accuracy, porosity, and mechanical stiffness were systematically investigated using a design of experiment approach.
In a two-level, three-factor factorial design of experiments, three niche factors, namely, culture dimensionality, fixed biochemical signal and mechanical stiffness, were simultaneously investigated.
Importantly, these spreading and migration patterns were consistently observed on both rigid and compliant substrates, thus differences in ECM mechanical stiffness were not the underlying cause.
Consequently, AH hydrogels having a defined polymer composition and mechanical stiffness were useful to successfully regulate chondrogenic differentiation and to maintain the chondrocytic cell phenotype, which may lead to many useful applications in cartilage regeneration.
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