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These data suggest that subtle mechanical signals generated during predominant activities such as posture may be potent determinants of skeletal morphology.
Mechanical signals generated by this extrinsic loading ultimately governed MSC fate, directing MSCs along a chondrogenic pathway as opposed to the default myogenic phenotype supported within unloaded fibrin clots.
Mechanical signals generated during walking on natural ground surfaces constitute a rich source of haptic sensory information [31] [33].
We further showed that the NF-κB pathway is involved in the transduction of the mechanical signals generated by DCS.
This study suggests for the first time that mechanical signals generated by a female fly have a prominent effect on males' courtship in the dark and leads the way to studying how multimodal sensory information and arousal are integrated in behavioral decision making.
Mechanical signals generated under normal physiological loading conditions will activate mechanotransduction pathways and drive biochemical events that regulate chondrocyte function and activity [ 1- 4].
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However, given our previous results during S phase in yeast, it is possible that transient mechanical signals are generated when forks approach LADs.
In addition to chemical signals that direct aspects of the wound response, mechanical signals are generated by the wound as the epidermis gapes open, and these could also impact on healing.
The anabolic potential of these vibratory mechanical signals that generate matrix deformations of less than 0.001% strain depended on the frequency at which they were applied, with the greatest response arising within the range of 20 100 Hz [7], [8].
This disparity in the activation of Rafs may play a critical role in the differential processing of signals generated by IL-1β and mechanical forces.
The feat is less a conceptual advance than another step in the years-long progress that researchers have made toward brain-computer interfaces, in which electrical signals generated from one brain are translated by a computer into commands that can move a mechanical arm or a computer cursor - or, in more and more studies, can affect another brain.
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