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Mechanical signals from the extracellular space are paramount to coordinate tissue morphogenesis and homeostasis.
Scientists are still sorting out exactly how cilia work, but some researchers theorize that they act as a cellular antenna, picking up both chemical and mechanical signals from the world outside.
It is interesting to note that SRF plays a central role in transducing mechanical signals from cell membranes to skeletal fiber nuclei via pathways involving integrin β1, RhoA and Focal Adhesion kinase [14], [48].
Considering that no extra growth factors were added, our results suggest that the biochemical and perhaps mechanical signals from each different peptide scaffolds induced the production of extracellular matrix proteins.
Recently, Dupont et al. [ 63] have shown that transcriptional coactivators YAP and TAZ act as sensors and relay mechanical signals from ECM proteins to alter cell behaviors.
The ECM is a fibrillar network composed mainly of collagen and Fn fibers and plays a vital role in regulating cellular responses to chemical and mechanical signals from the microenvironment.
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Figure 5 Results on the mechanical signal from the ball bearing plus noise.
The pattern of SPRY2 expression, and thus of Akt activation and branch initiation, was controlled by mechanical signaling from endogenous cytoskeletal contractility.
This study suggests that physical factors, beyond compliance, are involved in promoting existing invasive behavior in cancer cells and that mechanical signals transmitted from the physical activity of cells within the stroma may potentiate cancer progression.
It uses mechanical signals, resulting from forward mandibular positioning, to stimulate cellular proliferation in the condyle (Tang et al., 2004).
Fibroblast contraction is a key step in dermal wound healing, where mechanical signals derived from the extracellular matrix induce mechanoreceptor signaling and activation of the contractile machinery.
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