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Focal adhesions (FAs) play a central role in transducing mechanical signals between the cytoskeleton and ECM [8].
Last, but not least, it needs to be able to convey mechanical signals between the two heads.
Rho family GTPases function within epithelia to integrate and transduce bidirectional soluble and mechanical signals between the epithelial and stromal compartments [ 12].
The cell wall plays a central part in the transmission of chemical and mechanical signals between cells, and the positioning of developmental cues at the apex of sunflowers is reported to be sensitive to mechanical interventions [ 17].
The PCM plays an important role in many cell-surface phenomena; it transfers mechanical signals between the cell body and cell processes and between PCM and the surrounding extracellular matrix (ECM) [ 8– 13].
Mammary gland branching morphogenesis also requires reiterative interactions between the epithelial and stromal compartments, and both secreted factors and mechanical signals between the two compartments contribute to branch formation and patterning [ 9- 11].
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A picture is emerging that a tight integration of chemical and mechanical signalling between the lateral root and the surrounding tissue is essential for proper organogenesis.
Both molecular and mechanical signaling between cells in a growing tissue are affected by cell division.
Mechanical signals transferred between a cell and its extracellular matrix play an important role in regulating fundamental cell behavior.
Therefore, insights as to how mechanical signals are transferred between the cell and its surrounding three-dimensional collagen fibril network will provide a basis for designing the optimum extracellular matrix (ECM) microenvironment for tissue regeneration.
The cell-cell and cell-ECM junctions are also sites for both biochemical and mechanical signals to be transduced between the inside and outside of the cell.
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Justyna Jupowicz-Kozak
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