Sentence examples for mechanical sensitization in from inspiring English sources
In conclusion, MSG induced mechanical sensitization in masseter muscle and adverse effects such as headache and short-lasting blood pressure elevation for which tolerance did not develop over 5 days of MSG intake.
Repeated administration of the compounds was also effective in reducing the mechanical sensitization and oedema developed in the arthritis model induced by CFA.
However, no difference in mechanical sensitization was seen when capsaicin injections preceded Glu injections.
PKCε, a Ca2+-independent kinase investigated in various aspects of mechanical sensitization [39] [42], [87] [88] interacts with the C-terminus of TRPV4 in the presence as well as absence of Ca2+.
It is likely that oral MSG consumption increases glutamate concentration in the masseter muscle of human subjects and that this underlies the mechanical sensitization of the masseter muscle seen in the present study.
Thus, the lack of difference in pain intensity and mechanical sensitization when the two sessions were compared is unlikely to be a result of failure of the subjects to be exposed to increased systemic levels of Glu.
A genetic analysis of opioid-induced hyperalgesia in mice linked the β(2 -adrenergic receptor to mechanical sensitization after opioid exposure.
there is a rapid rise in glutamate concentration in the masseter muscle that is associated with significant mechanical sensitization of muscle nociceptors [15].
Further, it has been shown in rats that when the concentration of interstitial Glu in the masseter muscle was increased to ~75 μM, mechanical sensitization of the muscle nociceptors was maintained until the concentration dropped below 30 μM [13].
As already discussed, it is possible that glutamate concentrations in the muscles of healthy individuals were not elevated sufficiently to produce measurable mechanical sensitization after a single ingestion of MSG.
We hypothesized that increased interstitial Glu concentration in the masseter muscle after oral ingestion of MSG would increase Glu-evoked pain and jaw muscle mechanical sensitization compared to placebo.
