Sentence examples for mechanical sensitivity that from inspiring English sources

Thus, a subset of P-mTOR containing A-nociceptive primary afferents supported the increased punctate mechanical sensitivity that develops around a site of injury but did not influence peripheral sensitization or indeed the acute pain responses.

Following this, we tested the mechanical sensitivity that develops around the site of injection.

Capsaicin-insensitive A- fiber nociceptors are thought to mediate punctate secondary mechanical hyperalgesia, that is the mechanical sensitivity that develops around a site of injury [36].

We then showed with electromyographic studies that the mTOR inhibitor rapamycin reduced the sensitivity of a population of myelinated nociceptors known to be important for the increased mechanical sensitivity that follows injury.

Following this, we tested the punctate mechanical sensitivity that develops around the site of injection and found that it was blocked by rapamycin.

The SNI model has proved to be robust, with substantial and prolonged changes in mechanical sensitivity that closely mimic many features of clinical neuropathic pain [ 28, 29].

Compared with WT mice, genetic deletion of Hsp70 did not alter the severity of the deficits in mechanical and thermal sensitivity that had developed prior to drug treatment.

Whereas control and ND2 ins1 mutants were unaffected by mechanical stress, ND2 del1 mutants displayed bang sensitivity that progressively worsened with age (Fig. 1A; supplementary material Movie 1).

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The finding that over half of the TRPA1-transfected cells were not mechanically sensitive suggests that TRPA1 alone is not sufficient to confer novel mechanical sensitivity to a cell and that associated proteins present in native neurons may be required to recapitulate mechanically-gated currents.