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It is characterized by increased mechanical sensitivity observed 6 days after surgery in the spared sural territory, that is, the lateral part of the hind paw [ 44, 48].
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However, in response to 265 and 350 Hz stimuli, the maximum mechanical sensitivity is observed at low particle velocity between 0.3 and 4 mm/s, and decreases at the particle velocities above 4 mm/s.
DOI: http://dx.doi.org/10.7554/eLife.01488.012 Finally, we asked whether a small arbor with few transduction units can display a heightened mechanical sensitivity compared with a large arbor, as we observed in electrophysiological recordings.
We focused on spinal mechanisms by which 4E-BP1 controls mechanical sensitivity.
Finally, we extended the observation that rapamycin reduces secondary mechanical sensitivity to a model of neuropathic pain.
A loss of this correlation was clearly observed in mice treated during the first two weeks with electro-acupuncture (p.c.c. of 0.6-0.7 0.6-0.7hanical sensitivity (see Table 1) and reduced to 0.5 for heat sensitivity (see Table 2)).
Subsequently, the obvious stress-induced antinociception was observed in the wild-type and Per2 mutant mice, however, in Per1 mutant, this antinociceptive effects were partially-reversed (mechanical sensitivity), or over-reversed to hyperalgesia (thermal sensitivity).
The mechanical sensitivity, heat nociception, and cold allodynia were examined.
We tested the mechanical sensitivity following inflammation.
We then measured noxious thermal and mechanical sensitivity before (baseline, BL) and after mPAP injections.
Following this, we tested the mechanical sensitivity that develops around the site of injection.
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