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It should be noted here that the possibility that rapamycin is damping down a local inflammatory response in the paw, and so reducing inflammatory sensitivity is unlikely as the mechanical sensitivity in nerve injury models arises from the induction of central sensitization and the amplification of A-fiber responses-not local inflammation.
(E) Mechanical sensitivity in the contralateral leg to the inflammation.
Acupuncture reduced mechanical sensitivity in mice without caffeine (Before and After Acupuncture, both magenta and blue lines).
On the next day, mechanical sensitivity in the same mice was re-evaluated twice but with administration of caffeine at the acupuncture point 5 min prior to the acupuncture.
Finally, local injection of CXCL1 induced mechanical sensitivity in naive mice, whereas blocking CXCR2 reversed mechanical hypersensitivity after hind paw incision.
Determining the mechanical sensitivity in a system leads to a deeper understanding of both functional convergence and morphological diversification.
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The sensitivity of plant cell culture to fluid forces, or fluid-mechanical sensitivity, in a stirred bioreactor is evaluated by shearing the cells in viscometers for short duration under a range of laminar and turbulent conditions.
To quantify a known behavioral abnormality associated with neuropathy in mice, mechanical sensitivity was assessed in nondiabetic and diabetic ob/ob mice at 8, 9, 10, and 11 weeks of age.
In the acrolein model of bladder inflammation in rats, increased mechanical sensitivity was conveyed, in part, via NGF and trk receptors [ 83].
pafr−/− mice showed no major defects in basal mechanical sensitivity or motor coordination in the rotarod test [37].
However, mechanical sensitivity was reduced in TRPV2-deficient mice (Fig. 2c e).
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