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This information may help us to understand the mechanical roles in the extracellular matrix infrastructure, cell attachment, and to design tissue engineering and drug delivery systems where the mechanical functions of HA are essential.
Fibrocartilages, including the knee meniscus and the annulus fibrosus (AF) of the intervertebral disc, play critical mechanical roles in load transmission across joints and their function is dependent upon well-defined structural hierarchies, organization, and composition.
The present study uncovered a mechanism that coordinates the distinctly localized myosin IIA and myosin IIB with unexpected opposite mechanical roles in maneuvering lamellipodia extension, a critical step in the initiation of cell invasion, spreading, and migration.
These results together with a significant increase in retrograde flow of F-actin observed in growth cones of myosin IIB knockout mice [63] support the notion that myosin IIA and IIB play separate and opposite mechanical roles in mediating lamellipodia extension during cell migration.
They play both signaling and mechanical roles in cells.
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They have an indirect mechanical role in the alignment of collagen fibres in stress.
Vitreous humor (VH) is a gelatinous substance contained in the posterior chamber of the eye, playing a mechanical role in the eyeball.
The cardiac dystrophin-glycoprotein complex partially associates with costameric vinculin, suggesting a mechanical role in the maintenance of surface membrane integrity and membrane domain organization [ 50, 51].
Within the context of the axonal tension theory, axons have been considered to exert a mechanical role in the formation of sulci and gyri.
Thus, the ECM is not only a scaffold, having a mechanical role in supporting and maintaining tissue structures, but is also a complex and dynamic meshwork influencing many biological cell functions.
Extension of the conoid is associated with the elongation and narrowing of the apical end of tachyzoites, and it is believed that the conoid has a mechanical role in parasite invasion of host cells.
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