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Their mechanical role has been demonstrated in several studies, which includes analyses of disease mechanisms in the rapid aging disease progeria [12].
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Magnetic bead clustering has previously been used to study effects of both mechanical stress and receptor clustering in other systems, and a role has been suggested for mechanical triggering of TCR.
The role has expanded.
Extension of the conoid is associated with the elongation and narrowing of the apical end of tachyzoites, and it is believed that the conoid has a mechanical role in parasite invasion of host cells.
Thus, the ECM is not only a scaffold, having a mechanical role in supporting and maintaining tissue structures, but is also a complex and dynamic meshwork influencing many biological cell functions.
They have an indirect mechanical role in the alignment of collagen fibres in stress.
Indeed, the spatial variation in methyl-esterification levels at intercellular spaces suggests that HG has an in vivo mechanical role within the cell wall [ 12] and contributes to the mechanical properties to the wall.
Unlike the usual interface or enthesis between locomotive structures, mechanical roles of elastic fibers have been described in the vocal cord as well as the joints between ear ossicle [ 11– 13].
Role of mechanical force has been attributed to destabilizing H-bonds to allow for replacement with residue-solvent ones (35).
The role of mechanical forces has been experimentally tested in a small number of cell-surface and cytoskeletal proteins but never in the context of viral infection.
In this framework, an instructing role of mechanical forces has been successfully explored theoretically (Shraiman, 2005; Aegerter-Wilmsen et al., 2007) and there is today accumulating evidence that many molecular actors involved in development are under both biochemical and mechanical control.
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