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Of interest, a downregulation of FrzB was observed in human and mouse cartilage explants in response to mechanical injury, suggesting a de-repression of the canonical Wnt pathway [ 46].
Here we describe a comprehensive analysis of the thermodynamics of LacR-mediated repression, including a rigorous statistical-mechanical theory for DNA loop closure [22].
Applying our recent statistical-mechanical theory for DNA looping, we calculated repression as a function of operator spacing (58 156 bp) from first principles and obtained excellent agreement with independent sets of in-vivo data.
Here we provide a novel analysis of in-vivo gene repression from first principles based on a rigorous statistical-mechanical model of DNA looping.
Our results show that C. cinerea has the ability to discriminate between different abiotic (mechanical damage) and biotic stimuli, and respond to these stimuli by the induction or repression of specific gene sets.
In mechanical solidarity, people are self-sufficient, there is little integration and thus there is the need for use of force and repression to keep society together.
The sheer terror of the institutional violence and the dictatorships in South America has always verged on something that is beyond just a government's mechanical repression there was and is, when it surfaces, something more essentially evil about it.
More repression.
Maybe repression.
There was financial repression.
Repression was intense.
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CEO of Professional Science Editing for Scientists @ prosciediting.com