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Despite the importance of IF mechanics for cell biology and cell mechanics, the structural basis for their mechanical properties remains unknown.
The general problem of how to best correlate low-level shape data with the higher-order manufacturing and mechanical properties remains an open area of research with many practical applications (cost estimation, design archival, variational design and process selection).
Although various copolymerization methods have addressed needs of different applications, release of acidic degradation products, processing difficulties and limited range of mechanical properties remains as major disadvantages of this family of polymers.
However, the difference between in vivo and post-mortem mechanical properties remains poorly known, essentially due to the lack of a common method that could measure them both in vivo and ex vivo.
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Engineering a functional tendon with strong mechanical property remains an aim to be achieved for its eventual application.
Rubber nanocomposites with high gas barrier property have extensive application prospects in sealing and packing industry, while developing a novel and cost-effective rubber-based material with low gas permeability and good mechanical property still remains a challenge.
While atomistic simulations have become central to investigating its mechanical properties, the method remains prohibitively expensive for large deformations and mesoscale failure mechanisms.
However, designing injectable hydrogel scaffolds encompassing both adequate mechanical and biological properties remains a key challenge for in vivo applications.
The relation between the biological mechanisms of transcriptional control and the physical constraints put on these mechanisms as a result of the mechanical properties of the DNA remains unclear.
However, control of the mechanical properties of such surface remains challenging.
However, the fabrication of hybrid scaffolds with suitable mechanical properties and good biocompatibility remains a challenge.
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