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A shortcoming of most tissue engineered skin constructs is that they rely upon molecular diffusion and mechanical perfusion for nutrient supply.
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Four animals with bilateral lung lavage, high tidal volume mechanical ventilation, and perfusion block of the left lower lobe.
Thus, this study demonstrates the maturation of cardiac constructs with clinically relevant dimensions by the application of cyclic mechanical stretch and perfusion of the starter matrix.
The aim of this study was to investigate the impact of mechanical stimulation and perfusion on the maturation process of large-scale (2.5 × 4.5 cm), implantable cardiac patches based on decellularized porcine small intestinal submucosa (SIS) or Biological Vascularized Matrix (BioVaM) and a 3-dimensional construct containing neonatal rat heart cells.
The procedure of isolating NKT cells typically involves perfusion, mechanical segregation and gradient centrifugation [4].
Although not generally agreed, therapies based on the mobilization/injection of several types of stem cells have been shown to ameliorate the mechanical function and perfusion in ischemic cardiomyopathy [2] [4].
In dogs with experimental complete AV block, Mills and colleagues showed that LV apical and LV septal pacing resulted in only moderate electric desynchronization as well as in minor redistribution of mechanical work and perfusion [ 50].
A bioreactor was utilized to produce perfusion and mechanical stimulations.
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