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The advancement of 3D gait analysis has given a clearer insight into the complex interaction between the underlying mechanisms of inflammation and mechanical pathways that influence the development of foot problems in people with IA.
We propose that bacteria do not only hitch-hike chemical pathways for altering the behavior of their host cells but they also use rapid mechanical pathways.
This rich biological complexity provides many opportunities for the study of the fundamental mechanical pathways that have such clear importance in diverse aspects of cell biology.
Weight loss, insoles, modified footwear, strengthening exercises, knee braces and gait modifications have been suggested as means to lower knee joint loads and thus slow structural disease progression through mechanical pathways, 41 46 with effects yet to be proven.
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While a mechanical pathway between meniscal injury and OA has been described, the biological effects of inflammation on this pathway have yet to be clarified.
However, future studies are required to evaluate the possible interaction between these biological effects on the mechanical pathway for the development of knee OA after meniscal injuries.
This model decomposes the mechanical pathway of the signal into individual ultrasonic propagation layers which are generally independent of the layer׳s adjacent domains.
To explain such a mechanical pathway, it is essential to understand how forces can be transmitted to the nucleus.
Shear stress response elements contain a TPA response element to which NFκB, which is part of a main mechanical pathway, binds [ 33].
These effects suggest a possibility of thermo-mechanical pathways to disruption of irradiated DNA.
The studies highlighted within this review have identified an important role for mechanics in TGFβ-induced EMT and suggest that mechanical signaling pathways, including those involved in mechanotransduction, cell contractility, and regulation of matrix rigidity, could serve as potential targets for new therapies directed toward fibrosis and cancer.
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