In experimentally induced pain, women seem to be more sensitive to painful mechanical pressure, electrical stimulation and ischemic pain compared to men [ 22- 27, 27].
Temporal summation of heat pain [ 3] and mild noxious mechanical stimuli [ 4] results in increased report of pain compared to pain-free controls.
Dexmedetomidine reduced duration of mechanical ventilation compared with midazolam and improved the ability of patients to communicate pain compared with midazolam and propofol.
We found the differences in pressure pain thresholds maintained in our population suggesting greater mechanical pain sensitivity of the deep tissue in women when compared to men when a chronic pain condition such as OA is present.
The patients with RA, compared with healthy control individuals, had lower mechanical pain thresholds, lower heat pain thresholds, and lower cold pain tolerance, all of which are expected in a situation with peripheral sensitization to noxious stimuli [ 2].
Mechanical pain thresholds, however, were significantly increased in the BoNT‐A treated region compared to the vehicle control area (p < 0.001, BoNT‐A vs saline, 2‐way repeated measures ANOVA).
The mechanical pain thresholds on the knee were significantly decreased in the acute state of AIA compared with baseline values (p = 0.0058), demonstrating primary hyperalgesia at the inflamed knee.
To investigate the effect of unmodulated 5-kHz alternating current on mechanical pain threshold (MPT), heat pain threshold (HPT), tactile threshold (TT), and peripheral nerve conduction (PNC) compared with transcutaneous electrical nerve stimulation (TENS) and sham stimulation.
In contrast to mechanical pain, we found that thermal detection and pain thresholds were not significantly different when comparing BoNT‐A treated and saline‐treated skin (data not shown).
