Sentence examples for mechanical overloading of from inspiring English sources

Meniscal injuries can lead to mechanical overloading of articular cartilage and eventually to knee osteoarthritis.

In order to qualify residual stress relaxation as an indicator of mechanical overloading of machined parts, an individually designed residual stress profile has to be allocated.

Primary knee OA is frequently associated with mechanical overloading of joints (Kujala et al. 1994) and is characterized by degradation of the whole joint including cartilage, subchondral bone and surrounding soft tissue (Felson et al. 2000).

We had previously observed that mechanical overloading of murine IVDs results in altered MMP-2 activation patterns [ 10, 15].

Due to the fact that Asian countries have visibly lower overweight and obesity rates than European countries [ 35, 36] a higher failure rate caused by mechanical overloading of the components seems implausible.

This suggests that local factors such as mechanical overloading of the cartilage, rather than humoral agents affecting the whole joint such as cytokines or growth factors, play a significant role in regulating the metabolism of these proteins in cartilage in OA.

Mechanical overload of the heart is associated with excessive deposition of extracellular matrix proteins and the development of cardiac fibrosis.

In addition, Pufe and colleagues [ 14] have reported that mechanical overload of bovine cartilage discs leads to an increased expression of VEGF-A via HIF-1.

When mechanical overload of muscle occurs, the myofibers and extracellular matrix are disturbed, which in turn stimulates a process of protein synthesis [ 7].

The OsseoCare motor was developed to provide a well-controlled insertion torque to avoid mechanical overload of the equipment or bone tissue.

39 Again in OA mechanical overload (of the cartilage tissue) remains a key driver of pathology but the point is the evidence suggests it is mediated through elements of the inflammatory response.