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In conclusion, it is conceivable that the additional endothelial receptors for iRBC described here may contribute to the pathology of severe malaria and, in particular, of CM through a number of mechanisms, which, besides the mechanical obstruction of blood flow, possibly include interference with important functions of brain endothelial cells.
The simplest model involves the surgical creation of a mechanical obstruction of the gastroesophageal junction.
The most clinically important secondary causes that need to be differentiated include pseudoachalasia as a consequence of neoplastic infiltration of the gastroesophageal junction and mechanical obstruction of the junction by a surgically created fundoplication.
However, it remains unclear whether reduction of number of ICC primarily leads to mechanical obstruction of the bowel such as seen in intestinal atresia.
We report a case of a mechanical obstruction of the expiratory limb of the anesthesia circuit which went undetected before the induction of anesthesia.
Pulmonary arterial hypertension (PAH) is a disorder in which mechanical obstruction of the pulmonary vascular bed is largely responsible for the rise in mean pulmonary arterial pressure, resulting in a progressive functional decline despite current available therapeutic options.
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This sensitivity would be solely based on self-initiated movements and internal feedback derived from mechanical obstructions of the animal's body and does not require sensors triggered by events outside the body.
Hypertension is seen either due to mechanical obstruction, activation of the renin-angiotensin system, neural reasons and/or Goldblatt type phenomenon [1].
Apart from mechanical obstruction, vasoconstriction of the pulmonary vasculature plays a pivotal role in the acute rise in pulmonary artery pressure in patients with pulmonary embolism [ 9].
Catheter-associated venous thrombosis may occur from inappropriate positioning of the catheter tip, mechanical obstruction from precipitation of the fluid infused, or thrombosis of the catheter itself [13, 14].
In conclusion, these two cases illustrate that awareness of the possibility of true mechanical obstruction, as a complication of CIPS, is needed in CIPS patients without improvement of an exacerbation on conservative treatment.
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