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Early investigations into the mechanisms underlying mechanical modulation of pacemaker function utilized positive-pressure cell swelling as a mechanical stimulus.
We used MLO-A5 cells to develop a system for studying the mechanical modulation of bone matrix formation in 3D using a cyclic compressive loading stimulus.
Although growth plate response to mechanical stress has been increasingly studied, our understanding of mechanical modulation of neonatal growth plate is incomplete, especially concerning biochemical changes.
Moreover, mechanical interactions with a rigid extracellular matrix (ECM) are considered, and the mechanical modulation of growing tumors in a rigid surrounding tissue is investigated by means of numerical simulations.
All PAS measurements were performed at room temperature using 488-nm argon laser radiation for excitation and mechanical modulation of 9 and 30 Hz.
While interpreting these results, it is important to consider the role of the collagen scaffold, which is not inert, and may play a role in chemical and mechanical modulation of gene expression for example through integrin binding and mechanotransduction.
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Thus, hereditary and mechanical modulations of growth and development share a common pathway via genes.
A recent development of generalized Förster theory incorporating distance and torsional fluctuations pointed out that the deviation of the energy transfer process between metal nanoparticle and organic donor could originate from quantum mechanical modulations of donor-acceptor coupling [ 17].
It is well known that mechanical stimuli induce cellular responses ranging from morphological reorganization to mineral secretion, and that mechanical stimulation through modulation of the mechanical properties of cell substrata affects cell function in vitro and in vivo.
Based on quantitative characterization of the actin cytoskeleton remodeling during osteodifferentiation, we postulate that the actin cytoskeleton plays a pivotal role in determining the hMSC mechanical properties and modulation of cellular mechanics at the early stage of stem-cell osteodifferentiation.
Therefore, it is postulated that the actin cytoskeleton may play a pivotal role in determining the hMSC mechanical properties and modulation of cellular mechanics during stem-cell osteodifferentiation [82].
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