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Mechanical loadings that activated signal transduction pathways promoted drug resistance, stressing the importance of introducing mechanobiological cues into preclinical tumor models for drug screening.
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The results obtained in this study are useful in the mechanics of fracture initiation of saturated porous materials under the fluctuating mechanical and/or pore fluid loadings that are periodic with time.
Current field returns indicate that mechanical loadings are causing crack failures in dies and packages.
The relatively thin plate-type geometry provides susceptibility for mechanical failure under the extreme hydraulic loadings that the fuel is exposed to in-pile.
One of the putative reasons of OA development in the contralateral knees is that more focal mechanical loadings is applied to the contralateral mobile knees following OA progression in the immobilized knees [ 4, 24].
Results described that application of combined mechanical loadings had determinant effects on actin fiber structure and arrangement of cells describing more vivid and thicker fibers among samples treated mechanically in comparison to control samples.
Using a predictive bioinformatics algorithm, a recent study investigated the time-dependent regulatory mechanisms that governed mechanical loading-induced gene expression in bone.
They also prove that for the considered fibrous architectures and mechanical loadings, the motion and deformation of fibres is an affine function of the macroscale transformation.
RSA was performed with two different mechanical loadings, and the strain induced by increasing load was measured.
After that, rotating bending fatigue tests were conducted to introduce the mechanical loadings, and quantitative measurements of the residual stress were made during the fatigue tests.
Former studies have pointed out that even if intergranular oxidation still occurred, intergranular crack initiation was inhibited due to specific mechanical loadings which were identified as Portevin-Le Châtelier (PLC) plastic instabilities.
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