In addition, less is known about the mechanism of mechanical loading in human tendon development and maturation.
This discrepancy is supported by results from the experimental rat ICU model where unilateral passive mechanical loading in neuromuscular blockade, sedated and mechanically ventilated animals resulted in a significant muscle mass sparing effect (Renaud G, Llano-Diez M, Ravara B, Gorza L, Feng HZ, Jin JP, Cacciani N, Gustafson AM, Ochala J, Corpeño R, Hedström Y, Ford GC, Nair KS, Larsson L. 2012.
In contrast, the ventilatory adaptations to inspiratory mechanical loading in humans are believed to involve suprapontine mechanisms (see reviews in [ 6, 7]).
These results outline the importance of designing TMF tests and selecting the appropriate mechanical loading in order to accelerate testing and still trigger the same failure mechanisms as observed in-service.
Brown, R. A., Prajapati, R., McGrouther, D. A., Yannas, I. V. & Eastwood, M. Tensional homeostasis in dermal fibroblasts: mechanical responses to mechanical loading in three-dimensional substrates.
Grimston SK, Brodt MD, Silva MJ, Civitelli R. Attenuated response to in vivo mechanical loading in mice with conditional osteoblast ablation of the connexin43 gene (Gja1).
This review focuses on current strategies to evoke mechanical loading in hydrogel-based heart muscle engineering.
Sugiyama, T., Price, J. S. & Lanyon, L. E. Functional adaptation to mechanical loading in both cortical and cancellous bone is controlled locally and is confined to the loaded bones.
Willie, B. M. et al. Diminished response to in vivo mechanical loading in trabecular and not cortical bone in adulthood of female C57Bl/6 mice coincides with a reduction in deformation to load.
To evaluate the response of bone to 2 anabolic stimuli, teriparatide and mechanical loading, in subjects with spinal cord injury.
