The test matrix was defined based on the thermo-mechanical loading identified at different positions of actual turbine rotor blades.
Mechanical load has been identified as an essential factor in the development and maintenance of bone architecture and integrity [ 166, 167].
It is found that square-packing arrangements provide the best possible bounds for the thermal strains and coefficient of thermal expansion (CTE) of the graded multi-layer, among the different unit cell models examined; however, no unique bounds could be identified for mechanical loading.
Other potential mechanisms include cumulative mechanical loading and micro-trauma and proprioceptive deficits.
Therefore, the model establishes a structure mechanics interdependence of the fibrous matrices under large deformation, which can be utilized in identifying the appropriate structure and external mechanical loading conditions for the regeneration of load-bearing tissues.
Understanding the role of Cx43 in bone modeling and remodeling, and identifying the molecular mechanism for regulation of Cx43 hemichannel opening in response to mechanical loading for appropriate release of bone modulators is an endeavor of several laboratories including ours.
There is a possibility that other proteins, such as MRPL45, SLC1A3, UPF2 and ASPN identified in this study are involved in bone response to mechanical loading.
Since FN-fs share the same receptors as mechanical loading, the effect of oxygen tension on integrin signals should be explored to identify whether integrin agonists or fragment oxygen-sensitive antagonists could be developed with ex vivo physio-biomimetic models.
Altered tension of the tendon in full-thickness tear rather than in partial-thickness tear may also play a role in the enzyme differences identified, since MMP expression in tendon cells is known to be modulated by mechanical loading.
For instance, upregulation of SOST was identified (2.51-fold); SOST is an inhibitor of Wnt signaling that responds to mechanical loading in the proximal rat tibia and is associated with bone mass changes [ 31].
However, lipid-induced degradation has been previously identified as a primary cause of failure in long-term SIBS implants subject to mechanical loading.
