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Using a rabbit model, we demonstrated that mechanical loading applied to cancellous bone in situ increased bone formation and altered trabecular morphology.
We investigated the effects of mechanical loading applied in vivo to native cancellous bone in the rabbit on bone formation and trabecular realignment.
For example, mechanical loading, applied macroscopically, is transferred to the mechanosensitive osteocytes (residing in the lacunar pores), which then transduce the respective mechanical stimulus into biochemical responses affecting osteoblasts and osteoclasts in the vascular pores.
The obtained results have demonstrated that the ERR and the intensity of the mechanical stresses depend not only on the level of the mechanical loading applied, but also on the angle of the debonding at the fiber/matrix interface.
As reported in numerous studies, mechanical loading applied by exercise can result in increases in bone mass and strength [ 3– 6].
Furthermore, passive mechanical loading applied for 2.5 hours four times per day for 9 ± 1 days in immobilized, sedated and mechanically ventilated ICU patients improved the muscle fiber function by 35% without affecting muscle mass.
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Basically, there are no intensive mechanical loads applied on an orthopedic cast.
All of the abovedescribed systematic reviews reported that walking is not effective at preventing osteoporosis, as it only provides a modest increase in the mechanical loads applied to the skeleton.
The numerical results revealed that the interface at EST behaves similarly to one with two equal mechanical loads applied at both ends of the FRP plate.
While it seems certain that mechanical loads applied to stem cells regulate their self‐renewal and induce controlled cell lineage differentiation, the detailed molecular signaling mechanisms responsible for these mechano‐effects remain to be elucidated.
Creep significantly enhances the deformation near the groove without mechanical load applied on the specimen, while it contributes to length change rather than deformation of the groove as the load level increases.
More suggestions(12)
mechanical stretch applied
mechanical pressure applied
mechanical vibrator applied
mechanical vibration applied
mechanical friction applied
mechanical noise applied
mechanical strain applied
mechanical energy applied
mechanical force applied
mechanical process applied
mechanical ventilation applied
mechanical stimulation applied
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