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Since the system is linear, the maximum power transfer to the mechanical load occurs when the load is matched to the stereocilia.
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Thus, both the boost in contractility and the upregulation of proteins involved in metabolic pathways by elevated mechanical load occur in a calcineurin-dependent manner.
With increased amounts of mechanical loading, osteogenesis occurs.
The mechanical loading environment occurring in sheep and goats is well understood [ 7- 9] and they are easier to handle than pigs or horses, including anesthesia [ 10].
Part of this inconsistency between in vitro and in vivo mechanical load magnitude could occur due to the non-physiological conditions during cell culture, such as two dimensional culture conditions which lack the connections and constraints exerted on the bone architecture due to the presence of mineralized matrix.
However, since most polymers are relatively compliant and exhibit time-dependent behavior, such membranes are prone to deformation under mechanical loading that can occur during different stages of manufacturing as well as during separation.
We found no evidence of mechanical feedback: neither mechanical load nor loading rate detectably altered the mechanical properties of this embryonic tissue.
Mechanical load-induced osteogenic response occurs through deformation – strain – of loaded bone in a dose responsive manner.
Bone remodelling occurs as an adaptation to mechanical load according to Wolff's law.
SEM fracture surface observations allowed analyzing, at the local scale, the main deformation mechanisms occurring during mechanical loading.
The simulation results show a significant thermal and mechanical load maximum at the tool corner, where the maximal wear occurs.
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