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Low-magnitude mechanical load needs to be applied at high frequency in order to have an effect equivalent to high-magnitude mechanical load at lower frequency [ 16].
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We suggest that mechanical loads need to be greatly decreased on the proximal adductor tendon to allow a correct maturation of the ossification centre.
On Earth, the effects of gravity and mechanical loading are needed to maintain our bones.
A physical therapy program performs an important role after PRP injection treatment in patellar tendinopathy patients, because a mechanical loading is needed after this injection [ 30]. van Ark et al. [ 31] (prospective case-series study) reported the first results of a combination treatment of PRP injection followed by a well-described physical therapy program.
However, to understand the molecular mechanisms of mechanosensing and subsequent reinforcement of the mechanical coupling of the adhesion complex, further information on the response of other molecules of the adhesion complex to mechanical load will be needed.
In order to unravel the mechanisms of bone formation, scientists need to determine the mechanical load levels that trigger bone mass increase.
It was found that a 2.5 mm thick beam window is needed to sustain the mechanical load.
In contrast, in the treatment of large injuries, the scaffold needs to be able to withstand mechanical load and shear forces from the time of implantation.
The need for fibronectin in the sensing mechanism is also consistent with several reports that mechanical load alters the structure of the fibronectin molecule, specifically the synergy site [62] [65].
However, long-term results are missing where the durability of such coatings under high mechanical load and its galvanic corrosion properties in direct contact with other metal implants (e.g. plate and screws) need to be tested.
Morse, A. et al. Mechanical load increases in bone formation via a sclerostin-independent pathway.
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