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In addition, it should be realized that an increase in muscle mRNA in response to activity or mechanical load does not necessarily induce' a higher protein production.
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In this case, the mechanical load did not represent a stimulus for the synthesis of pro-MMPs and their eventual activation.
Analysis of experimental data in the framework of the coarsening concept reveals that mechanical loading does not induce rejuvenation of glassy polymers, but results in an increase in the relaxation rate in accordance with the theory of thermomechanically activated processes.
Moreover, we show that mechanical loading did not modify its expression.
Compared to the NS group, mechanical loading did not significantly alter the parameters of bone microarchitecture within 0.5 mm of the test implant).
The results thus demonstrate a decline in TA CSA proportional to the length of the ICU stay, but mechanical loading did not influence the overall TA muscle CSA.
However, Wolff's 'Law', which postulates that bone increases in density and/or cortical thickness in response to the loads it is placed under during an individual's life, does not always hold, although rules for 'bone functional adaptation' to mechanical loading do exist ([ 27], p. 484; [ 28, 29]).
As we selected a stimulus not directly affected by mechanical load, we don't think this evidence is relevant to interpretation of our results.
The debt load doesn't worry Fisher.
Mechanical loading alone did not cause Smad1/5/8 activation.
Because mechanical loading to osteoblasts does not alter the expression levels of BMP-2 (Figure S2), these results suggest that mechanical stress to osteoblasts enhances BR-Smads phosphorylation without stimulation by BMP.
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