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If cochlear thresholds were within the normal range, the animal was randomly assigned to either the sham group, acoustic trauma or mechanical lesion group.
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For mechanical lesions groups, a small hole was hand drilled in the wall of the cochlea at the level of the basal turn.
Though rarely performed within any age group, MC-associated outpatient visits were most frequently accompanied by mechanical lesion disruption among patients in the 20 44 and 45 64 year old age groups, accounting for only 4.3% and 9.2% of visits, respectively.
Lesioned animals were divided in a low lesion group (LL, <50% neuron loss) and a high lesion group (HL, ≥50% neuron loss).
Lesioning caused a decrease in the metabolite concentration ipsilateral to the lesion, with the level for severely lesioned (>80%) rats being significantly lower than those for both the control group and the <80% lesion group.
The extra-frontal lesion group performed worse on the problem solving task than the control group.
When this occurred, presumably due to mechanical lesion at the rod RBC contact, Ih often disappeared as well.
The Control and Lesion+Matrix groups were significantly (P<0.01) lower from the Lesion group.
Both lesion groups ("early" pre-acquisition and "late" post-acquisition lesions) demonstrated increased reaction times to S1, with the late-lesion group also recording reduced task accuracy when compared with the sham control group.
There were few behavioral differences between lesion groups when interacting with the pregnant females.
After the lesioning of the late-lesion group, both lesion groups demonstrated reduced accuracy to the S2 stimuli as the control group improved their performance throughout the test period, while the accuracy of both lesion groups remained stable at a lower performance level.
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