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Previously we have reported that BmK I induced a mirror-image mechanical hypersensitivity where injection of BmK I at one side of hind paws caused mechanical hypersensitivity on both sides of hind paws.
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DOI: http://dx.doi.org/10.7554/eLife.12002.007 Next, we investigated the molecular and cellular mechanisms underlying the mechanical hypersensitivity of Eif4ebp1-/ mice.
Our recent studies have demonstrated increased TRPV1-immunoreactive nerve fibres in inflammatory bowel disease [ 23], and in the mucosal and sub-mucosal layers of patients with rectal hypersensitivity, where they correlated with thermal and mechanical hypersensitivity, suggesting increase of polymodal nociceptors [ 20].
Csf1 deletion from sensory neurons prevents nerve injury-induced mechanical hypersensitivity for at least 4 weeks.
In contrast, intrathecal injection of CSF1 induced mechanical hypersensitivity and microglial proliferation.
Wetzel, C. et al. Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.
Seal, R.P. et al. Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors.
Cre-mediated sensory neuron deletion of Csf1 completely prevented nerve injury induced mechanical hypersensitivity and reduced microglial activation and proliferation.
Effects of silencing the MCC or hind limb area of the primary somatosensory (S1HL) activity on capsaicin-evoked secondary mechanical hypersensitivity in the paw.
Furthermore, we found that intrathecal injection of desCER induces mechanical hypersensitivity in a dose dependent manner.
In addition, spread of mechanical hypersensitivity beyond the facial region was noted.
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