Sentence examples for mechanical hypersensitivity of from inspiring English sources
DOI: http://dx.doi.org/10.7554/eLife.12002.007 Next, we investigated the molecular and cellular mechanisms underlying the mechanical hypersensitivity of Eif4ebp1-/ mice.
It has been also reported that NMDA receptor antagonists (DL-2-amino-5-phosphonovaleric acid and Ifenprodil) blocked CFA-induced mechanical hypersensitivity of the TMJ region and the constitutive expression of NMDA receptor subunits in the TG [5].
10.7554/eLife.12002.009 Figure 4. Enhanced expression of neuroligin 1 contributes to mechanical hypersensitivity of Eif4ebp1 -/- mice.
TRPA1 has also been linked to mechanosensation, although it appears to mostly contribute to mechanical hypersensitivity of afferents after inflammation.
Taken together, our data demonstrate that elevated levels of neuroligin 1 contribute to the mechanical hypersensitivity of Eif4ebp1-/ mice.
The mechanical hypersensitivity of all the groups was assessed by means of Von Frey hair (VFH), for up to 24 h after carrageenan administration, as described below.
Interestingly, a knockdown of Clcn3 expression in DRG was associated with exaggerated mechanical hypersensitivity to plantar application of von Frey stimuli in tumour-bearing mice.
Although mice treated with a miR-483-3p-mimic miR-483-3p-mimic miR-483-3p-mimic miR-483-3p-mimicto 0.07 g of mechanical force following tumour indevelopedsignificantto basal behaviour, the mechanicalof mechypersensitivitysitovity observed was significantly lesser as compared to that seen in mice treated with a non-targeting control mimic (Fig 4, panel C).
Mice treated with the mismatch inhibitor developed significant plantar mechanical hypersensitivity to von Frey force of 0.07 g (Fig 3, panel C), with the same time course and amplitude as untreated mice (Fig 1A).
Interestingly, mice treated with a miR-370-3p-mimic miR-370-3p-mimic miR-370-3p-mimic miR-370-3p-mimicical hypersensitivity to a von Frey force of 0.02 g than mice treatedevelopednon-targeting control mimic (Fig 4, panel A; p < 0.05).
Mechanical hypersensitivity, characteristic of neuropathic pain, does occur but only later in life.
