Sentence examples for mechanical hypersensitivity observed from inspiring English sources
Administration of alosetron (5-HT3 receptor antagonist), either intravenously or intrathecally, reverses the mechanical hypersensitivity observed after acid saline injections and prevents the development of visceral hyperalgesia (male rats) [ 70].
Although mice treated with a miR-483-3p-mimic miR-483-3p-mimic miR-483-3p-mimic miR-483-3p-mimicto 0.07 g of mechanical force following tumour indevelopedsignificantto basal behaviour, the mechanicalof mechypersensitivitysitovity observed was significantly lesser as compared to that seen in mice treated with a non-targeting control mimic (Fig 4, panel C).
Development of significant mechanical hypersensitivity was observed in CCI rats after postoperative day 4 (P < 0.05 vs. sham) and heat hypersensitivity developed after postoperative day 2 (P < 0.05 vs. sham).
DOI: http://dx.doi.org/10.7554/eLife.12002.007 Next, we investigated the molecular and cellular mechanisms underlying the mechanical hypersensitivity of Eif4ebp1-/ mice.
We previously observed that rats with CP showed persistent mechanical hypersensitivity in the abdomen [ 11].
Furthermore, we confirmed that the loss of these background cold and mechanosensitive potassium conductances (Maingret et al, 2000) leads to a mechanical hypersensitivity (Alloui et al, 2006; Noel et al, 2009) comparable with that observed in wild type animals with oxaliplatin treatment.
In this context, in the absence of inflammatory cell infiltrate, such as in IL-17 knockout mice, a significant decrease in mechanical pain hypersensitivity was observed [ 43].
This IB4/NGF fiber population either does not express TRPV1 or TRPV1 does not mediate mechanical stimulation in these fibers, as we did not observe a direct involvement of TRPV1 in SCC-induced mechanical hypersensitivity.
Functional validation of miRNAs upregulated in DRGs in tumour-bearing mice with respect to tumour-induced mechanical hypersensitivity.
Functional validation of miRNAs downregulated in DRGs in tumour-bearing mice with respect to tumour-induced mechanical hypersensitivity.
However, not all of the miRNAs which were observed to be upregulated in DRGs following tumour induction emerged as functionally relevant in the context of tumour-associated mechanical hypersensitivity.
