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A better understanding of the relationship between structure and mechanical function is expected to be important for the current trends in (bio materials design, where the structure of biological materials is considered as a possible source of inspiration, as well as for more successful approaches in the prevention and treatment of age- and disease-related fractures.
This study was designed to determine the contribution of left atrial (LA) stiffness to atrial fibrillation (AF) progression by comparing AF patients with normal control subjects, and to evaluate whether LA mechanical function is related to the structural changes of LA.
Left atrial enlargement with impaired mechanical function is often observed in healthy humans after the eighth decade.
Yet, how exactly normal LV mechanical function is linked to deformations of the underlying anatomical structure remains unclear.
Cartilage tissue mechanical function is determined by the hierarchy of structure and collagen/aggrecan mechanical properties arising from the nanoscale.
Left ventricular (LV) mechanical function is determined by passive and active myocardial mechanical properties and by 3D structure and geometry (which also affects electrical properties), as reviewed elsewhere.
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Cardiac geometry and mechanical function were evaluated by echocardiography and cardiomyocyte and intracellular Ca2+ properties.
While matrix deposition has been observed in parallel with improved mechanical properties, how composition, organization, and mechanical function are related is not known.
While mechanical function was assessed and tensile modulus increased with culture duration, dynamic culture did not result in any additional improvement beyond free-swelling culture.
Wild-type FVB and transgenic mice overexpressing ALDH2 were challenged with ethanol (3 g/kg/day, ip) for 3 days and cardiac mechanical function was assessed using the echocardiographic and IonOptix systems.
Wild-type (WT) and transgenic mice overexpressing ALDH2 driven by chicken β-actin promoter were challenged with doxorubicin (15 mg/kg, single i.p. injection, for 6 days) and cardiac mechanical function was assessed using the echocardiographic and IonOptix systems.
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