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Mechanical force results from continuous stomach contraction that imposes a considerable force on foods and causes their disintegration.
Exposure of cells to mechanical force results in activation of numerous intracellular signaling pathways including protein kinases such as protein kinase C, c-Jun N-terminal kinases (JNK), extracellular signal-regulated kinases (Erk), and others (see [ 96] for recent review).
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Consequently, this process requires significant mechanical force, resulting in high elasticity.
However, the mechanisms by which bone cells sense mechanical forces, resulting in increased mineral deposition, are not well understood.
The morphologies of the molecular machines can be controlled by macroscopic mechanical forces, resulting in optimization of structure for molecular sensing.
Based on our previous findings (Bermejo et al., 2011), we reasoned that lamin-associated chromatin might mediate the transfer of mechanical forces resulting from DNA torsional stress to the NE.
figshare: Data on the effects of local membrane deformation and micro-injury in osteoblasts, doi: http://dx.doi.org/10.6084/m9.figshare.1091356 The article by Lopez-Ayon et al. compares the calcium (Ca 2+) response of osteoblasts to mechanical forces resulting from 2 types of well-defined micro-damages, namely a local membrane deformation and a micro-injury.
It is therefore likely that activation of the titin kinase via mechanical force may result in regulation of its proximal substrates via phosphorylation.
The outcomes show that the hybrid electrode could resist mechanical force and the results are better than original ITO electrode.
The decreased expression of type IX collagen in the cartilage may render the matrix more subject to mechanical forces, thereby resulting in the pathogenesis of human OA.
Promisingly, bioengineering-oriented research has advanced our understanding of the nature of the mechanical forces and resulting head and brain motion during TBI.
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