There is therefore a requirement for substrates and porous scaffolds which provide an appropriate chemical and mechanical environment for cell attachment, growth, proliferation and differentiation.
The optimal mechanical environment for fracture healing is still not exactly defined, but axial micromotions and compressive stress at the fracture site are considered beneficial for bone healing [3, 4, 5].
An often-proposed tissue engineering design hypothesis is that the scaffold should provide a biomimetic mechanical environment for initial function and appropriate remodeling of regenerating tissue while concurrently providing sufficient porosity for cell migration and cell/gene delivery.
However, although SMO can alter the weight-bearing axis, which provides an ideal mechanical environment for halting degenerative changes in the articular cartilage, the overall long-term success of SMO remains debatable if cartilage regeneration of medial osteoarthritic lesions is not achieved.
Placing these strain magnitudes in the context of literature on bone adaptation to mechanical loads, this study suggests that porous PEEK structures may provide a more favorable mechanical environment for bone formation and maintenance under spinal load magnitudes than currently available porous 3D-printed Ti, regardless of the level of bone ingrowth.
Rehabilitation aims to enable return to full sporting activity, prevent reinjury and minimise the progression to OA by facilitating a mechanical environment for the local adaption and remodelling.
Our previous study showed that PEG hydrogel with desired mechanical property could be prepared via controlling the concentration of PEG(400 DA solution and stereolithography parameters [ 35] PEG hydrogel might provide biomimetic mechanical environment for osteochondral repair.
In particular, in the study by Fröhlich and collaborators [ 102] ASCs were seeded on decellularized native bone scaffolds, providing the necessary structural and mechanical environment for osteogenic differentiation, and cultured in a perfusion bioreactor.
Fracture reduction with nonanatomic positive medial cortical support allows limited sliding of the head neck fragment to contact with the femur shaft and achieve secondary stability, providing a good mechanical environment for fracture healing.
PMCS reduction is a key element for stability reconstruction for unstable fractures, as it allows limited sliding of the head neck fragment after operation (fracture impaction) to contact with the femur shaft and achieve secondary stability, providing a good mechanical environment for fracture healing.
