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There is therefore a requirement for substrates and porous scaffolds which provide an appropriate chemical and mechanical environment for cell attachment, growth, proliferation and differentiation.
The optimal mechanical environment for fracture healing is still not exactly defined, but axial micromotions and compressive stress at the fracture site are considered beneficial for bone healing [3, 4, 5].
An often-proposed tissue engineering design hypothesis is that the scaffold should provide a biomimetic mechanical environment for initial function and appropriate remodeling of regenerating tissue while concurrently providing sufficient porosity for cell migration and cell/gene delivery.
However, although SMO can alter the weight-bearing axis, which provides an ideal mechanical environment for halting degenerative changes in the articular cartilage, the overall long-term success of SMO remains debatable if cartilage regeneration of medial osteoarthritic lesions is not achieved.
Placing these strain magnitudes in the context of literature on bone adaptation to mechanical loads, this study suggests that porous PEEK structures may provide a more favorable mechanical environment for bone formation and maintenance under spinal load magnitudes than currently available porous 3D-printed Ti, regardless of the level of bone ingrowth.
Rehabilitation aims to enable return to full sporting activity, prevent reinjury and minimise the progression to OA by facilitating a mechanical environment for the local adaption and remodelling.
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Failure to recognise the need for appropriate biological and mechanical environments for fracture union will lead to delay in healing and significant patient morbidity.
The simulation results revealed that a glass/polypropylene fabric composite (Twintex [0]2nT) IM nail, which has the similar Young's modulus to the cortical bone, provided the most appropriate bio-mechanical environment for bone healing.
One key feature of the database is able to map globally the mechanical environment of cells and provide the quantitative information for transcripts and proteins from various sources.
Consequently, simulation of bionic mechanical environment of a normal articular cartilage is considered to be the optimal environment for culturing the functional articular cartilage in vitro.
Mechanical principles are being used to develop scaffolds for tissue engineering and to optimise the mechanical environment of seeded mesenchymal stem cells.
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