Understanding how bone cells sense and react to mechanical forces is important for gaining insight into the mechanisms of bone adaptation to its mechanical environment.
These properties can be tuned to adjust microgel mechanics in order to control response to the surrounding (mechanical) environment.
However, the mechanisms that control postnatal skeletal integrity in a dynamic biological and mechanical environment are distinct from those that regulate bone development.
While extensive knowledge has been gained regarding the effects of the mechanical environment on cells and tissues, many questions remain regarding the molecular mechanisms of these effects.
Furthermore, tendons are sensitive to their mechanical environment [18-22] [18-22]
Also, there is no publication that has evaluated the mechanical environment considering the principal stresses.
Thereby, mineralization and tissue reformation by osteoblasts are co-related to the local mechanical environment [44].
Cells sense their mechanical environment, which, in turn, regulates their functions.
It has proved challenging to characterize the mechanical environment of bone cells in vivo, and the mechanical environment of osteoporotic bone cells is not known.
Cyclical loading with the failure of bone to adapt to its mechanical environment leads to stress fracture.
Furthermore, it is common practice to 'offload' the repair tissue with a realignment osteotomy to improve the mechanical environment.
