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More precisely, not absolute airway pressure but the transpulmonary pressure termed lung stress, and not the absolute tidal volume, but its relation to the FRC, termed lung strain, are mechanical determinants of VILI [ 5].
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To reveal a mechanical determinant that may mediate the antimicrobial activities, we examined the mechanical properties and structural stabilities of HP(2 20) and its four analogues of same chain length by steered molecular dynamics simulation.
Results indicate that architectural parameters, such as the bone volume fraction (BV/TV), are as strong determinants of mechanical response parameters as ultimate stress at high strain rates p-value<0.001 p-value<0.001
Our findings provide evidences that mechanical factors are key determinants of lubricin metabolism in vivo.
It is well established that mechanical forces are major determinants of bone mass (Harada and Rodan 2003).
In this study, we investigated whether proinflammatory factors and mechanical compression, the main determinants of OA, may lead to the expression and the release of NGF by chondrocytes.
Taken together with the altered lubricin level and gene expression patterns subjected to different running-induced loads, this investigation further supports the hypothesis that mechanical factors are key determinants of lubricin metabolism in vivo.
Collagen is the protein primarily responsible for the load-bearing properties of tissues and collagen architecture is one of the main determinants of the mechanical properties of tissues.
Surface and mechanical properties of the biomaterials are determinants of cellular responses.
Studies on the microstructural and mechanical properties of tibial cancellous bone by Ding and colleagues have revealed that the SMI and the bone volume fraction can be primary determinants of cancellous bone mechanical properties [ 34].
The combination of both mechanisms is believed to represent the major determinants of the depression of cardiac output during mechanical ventilation [ 32].
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