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Here we report that tamoxifen induces the mechanical deactivation of HSCs via a previously unidentified mechanism that involves the GPER/RhoA/myosin axis.
These results support the notion that tamoxifen promotes mechanical deactivation in HSCs through GPER/RhoA signalling.
This mechanical deactivation is mediated by the GPER/RhoA/myosin axis and induces YAP deactivation.
The deactivation phenomenon has different origins that can be divided into three groups: thermal, chemical and mechanical deactivation.
Similar(56)
As (i), (iv), and (v) are chemical in nature and (ii) and (v) are mechanical, the causes of deactivation are basically three-fold: chemical, mechanical and thermal.
The elective deactivation of mechanical cardiac assist devices has different legal and ethical consequences in non-futile situations compared with futile situations [ 12].
What are the mechanisms of immune deactivation?
Like the sensorimotor regions, this thinning in the CC was colocalized with bilateral BOLD signal following allodynic mechanical stimulation, in this case deactivation.
Recent evidence suggests that besides leukocyte activation in the circulation mediated by membrane receptors that are stimulated by humoral chemotactic factors, leukocyte activation and deactivation may also be regulated by mechanical fluid stresses.
Since we observed tamoxifen to inhibit these mechanical properties, we assessed whether tamoxifen could promote HSC deactivation.
Temperature control and catalyst deactivation, e.g. caused by fouling and mechanical stress, were key issues of investigation.
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