Sentence examples for mechanical cues of from inspiring English sources

Therefore, our results suggest that the TRPC6 activation mainly occurs at lipid rafts, which is regulated by the mechanical cues of surrounding materials.

Biomaterials are an integral part of this engineering toolbox and can exploit the intrinsic biological and mechanical cues of the immune system to directly modulate and train immune cells and direct their response to a particular phenotype.

The results indicated a desirable biocompatibility and mechanical cues of the multilayer nanofibrous scaffolds supporting structural stability and controlled release of the protein, which can offer diverse applications in hollow organ tissue engineering.

As an emerging tool in tissue engineering, 3D bioprinting technology relies heavily on biomaterials as bioink for structural support and sites for attachment of biological and mechanical cues of the laboratory-engineered tissue constructs and organs.

Paul George, MD, PhD along with Sarah Heilshorn, PhD have received a 1 year award from the Wu Tsai Neurosciences Institute to develop a protein-engineered nerve implant that mimics the biochemical and mechanical cues of native tissue in order to enhance the potential for neural regeneration following injury.

In particular, electrospun nanofibers composed of biodegradable polymers can mimic the topographical and mechanical cues of dense fibrocartilaginous tissues, driving fibrochondrogenic differentiation of seeded mesenchymal stem cells (MSCs) (Baker et al. 2010) and enhancing neotissue formation when placed within a vertical tear in vivo (Baker et al. 2012; Qu et al. 2015).

This review surveys the impact of mechanical cues on formation of vascular networks in 2D and 3D gel matrices.

Further studies are necessary to define the role of MRTFA in the regulation of epithelial markers during EMT and to determine the impact of mechanical cues on the loss of epithelial features during EMT.

Similarly, the effects of mechanical cues on extracellular matrix (ECM) production as well as cell adhesion and proliferation have been assessed using PEGDA hydrogel systems.

The effects of mechanical cues on cell behaviors in 3D remain difficult to characterize as the ability to tune hydrogel mechanics often requires changes in the polymer density, potentially altering the material's biochemical and physical characteristics.

Wide interest was generated in the influence of mechanical cues on cell differentiation following the demonstration that stem cells are primed for differentiation by the stiffness of their substrate, with rigid, stiff, or soft substrates supporting osteogenic, myogenic, or neurogenic differentiation, respectively.