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In the body, cells dynamically respond to chemical and mechanical cues from the extracellular matrix (ECM), yet precise mechanisms by which biophysical parameters (stiffness, topography and alignment) affect cell behavior remain unclear.
A term used to define receptors capable of receiving and translating mechanical cues from the environment.
Directionality of CNC cell migration also relies upon the non-canonical Wnt/planar cell polarity (PCP) signalling pathway18,19, which even influences mechanical cues from the underlying mesoderm tissue to regulate CNC migration20.
Cellular decisions are guided by biochemical and mechanical cues from their immediate microenvironment that consists of the extracellular matrix (ECM), neighboring cells and soluble factors.
Because breathing constitutes a sustained motion synonymous with life, pulmonary cells are normally designed to support permanent cyclic stretch without breaking, while receiving mechanical cues from their environment.
In addition to their structural complexity, cnidocytes display complex sensory attributes, integrating both chemical and mechanical cues from the environment into their discharge behavior.
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In this study, we test the hypothesis that hESCs accept mechanical cues for differentiation from the substrate by culturing them on flexible polydimethylsiloxane (PDMS) of varying stiffness.
Peripheral nerve regeneration can be enhanced by chemical and mechanical cues for neurite growth.
Lastly, we consider possible mechanical cues resulting from these changes and their potential influence on cell proliferation.
A synergistic effect of biochemical and mechanical cues emanating from the extracellular matrix (ECM) on inducing malignant transformation of epithelial cells has been observed recently.
The G1 surface enables a substrate design based on the mechanical cues in the microenvironment from feeder cells to expand undifferentiated hiPSCs in long-term culture.
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