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Here, we examined whether hPDC differentiation is regulated by adhesive and mechanical cues comparable to that reported for hBMC differentiation.
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Assisted by many biophysical studies, especially by structural and single-molecule studies, the molecular mechanism by which the cadherin complex senses mechanical cues has been gradually unveiled.
As such, adhesive and mechanical cues will need to be optimized for each MSC source in order to fairly compare differentiation of different stem cells.
Peripheral nerve regeneration can be enhanced by chemical and mechanical cues for neurite growth.
Other than providing soluble cues, nanoparticles have also been shown to provide mechanical cues responsible for stem cell fate determination, tissue formation, and organ regeneration.
Mechanical cues and sustained biological cues are important factors, particularly in load-bearing tissues such as articular cartilage or bone.
Incorporation of physiochemical, biological and mechanical cues along with these scaffolds improves the quality and durability of the ECM substitutes.
Chondrogenesis is known to pertain to chemical, topographical, and mechanical cues in the microenvironment.
Mechanical cues themselves have numerous parameters such as strain magnitude, frequency, and stimulation time.
Bone is capable of adapting its mass and structure under mechanical cues.
The latter is achieved through both mechanical cues – which act as stimulation factor and influences nutrient transport – and adhesion to extracellular matrix cues – which determine cell shape.
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