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The choice of agitation conditions (impeller type, rotational speed…) in this type of process is not an easy task as it has to fulfil three potentially conflicting goals: (1) maintaining microcarriers in complete suspension, (2) homogenizing the culture medium, and (3) limiting mechanical constraints generated by the hydrodynamics on the cells.
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In general, the extra constraints generated take the form (4).
The additional constraints, generated by the adaptive grid procedure, are embedded into the economic optimization problem.
To focus the search, our algorithm is guided by constraints generated from the task specification.
Prior knowledge was represented as pairwise constraints generated from class labels.
Furthermore, extrinsic factors can generate excessive mechanical constraints on the SSC tendon.
Furthermore, these islands were found to be efficiently generated by both lateral contacts and mechanical constraints applied to the main body of the microtubules.
In addition, body size generally affects overall mass and body proportions due to the mechanical constraints inherent in biological materials [60].
But, the throughput is limited by the mechanical constraints.
Moreover, the mechanical constraints they produce increase more slowly with the N/Njs ratio than the mechanical constraints produced by other impellers.
In computational motor control several studies have investigated internal models (inverse, forward) by manipulating mechanical constraints.
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CEO of Professional Science Editing for Scientists @ prosciediting.com