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Because hypertrophic chondrocytes expand their volume 5 10 fold (Buckwalter, 1983; Hunziker et al., 1987), experiencing stretch-induced load over a period of ∼48 hours (Farnum and Wilsman, 1993), we hypothesise that this mechanical challenge causes membrane rupture and lysosomal exocytosis in hypertrophic chondrocytes.
Similar(59)
In a biofilm, bacterial adhesion to a substratum surface causes a phenotypic change that makes removal upon a mechanical challenge more difficult (Vuopio-Varkila and Schoolnik 1991; Gonzalez-Valencia, Munoz and Torres 1991; Pal et al., 1992; Kallman et al., 1993).
"It's a big mechanical challenge for us," said William M. Mensching, the president of Showmotion.
"It's one of the toughest mechanical challenges".
Defining mechanical engineering is in itself a challenge.
Mechanical ventilation causes mechanotransduction and cell and/or tissue damage.
Mechanical activity causes physical deformations of the sensor's geometry.
The loss of mechanical resistance causes complete tears.
However, mechanical stress causes joint diseases, and excessive mechanical stress may lead to the development of OA.
Investigation revealed both mechanical and organizational causes of the accident.
However, whether mechanical causes influence the process remains unclear [ 7].
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