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Both mechanical and systemic mechanisms have been put forth to explain the effect of obesity on hand OA, but the reason for this association is currently unknown [ 24].
It is certainly biologically plausible that also overweight could cause or contribute to LBP; both mechanical and systemic changes have been suggested [ 20].
The contact with the bone matrix is a critical mechanism providing cues via cytoplasmic processes called canalicules to form a cellular network to sense efficiently both mechanical and systemic stimuli [ 7].
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Complex interactions of genetic alterations, sex hormone deficit, and aging with mechanical factors and systemic inflammation-associated metabolic syndrome lead to joint damage.
As such, osteoblasts respond to many mechanical, local and systemic stimuli that regulate mineralization while orchestrating bone remodeling.
This was the first study to show a link between mechanical ventilation strategies and systemic organ injury in animals, suggesting that mechanical ventilation at tidal volumes greater than those commonly used to treat patients with ARDS might contribute to both pulmonary and distal organ injury [ 8, 9].
It is driven by numerous mechanisms including mechanical stress and local and systemic neurohumoral pathways such as activation of the renin angiotensin system.
The ELISA readings (OD405) averaged 0.22 ± 0.02 at 0 to 6 days after mechanical inoculation in inoculated and systemic leaves (Figure 5).
Relevant pediatric literature Anesthesiologist-performed ultrasound allows for visualization of peripheral nerves and their surrounding anatomy in real time, thereby enabling reliable drug delivery to the target nerve while avoiding mechanical nerve injury, local and systemic drug toxicity, or injection into adjacent structures in pediatric patients [392 394].
Intervertebral disc (IVD) degeneration is considered to be a multifactorial process involving mechanical, genetic, systemic, and biological factors.
Furthermore, mechanical ventilation can influence both local and systemic immune responses [ 1] because mechanical forces within the lungs trigger different biological responses that spread into the systemic circulation.
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CEO of Professional Science Editing for Scientists @ prosciediting.com