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Fortunately, the impact of myoglobin on NIRS for measuring tissue oxygenation is minimal [17, 18] and melanin, due to its superficial localization, is not a major issue in this regard.
The computerized polarographic needle electrode system (pO2 histography) represents one standard for measuring tissue oxygenation in human malignancies [ 28].
As a standard for measuring tissue oxygenation in human tumors, the invasive, computerized polarographic needle electrode system (pO2 histography) was used for comparing the different non invasive measurements.
Fortunately, the impact of myoglobin on NIRS for measuring tissue oxygenation is minimal [ 17, 18] and melanin, due to its superficial localization, is not a major issue in this regard.
In a prospective study we were able to validate FMISO PET for determination of radiotherapeutically relevant hypoxia by gold standard for measuring tissue oxygenation in human tumors, the computerized polarographic needle electrode system in patients with metastatic neck lymph node from a primary squamous carcinoma of the head and neck.
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It can be used to indirectly measure tissue oxygenation with high spatial resolution.
These results demonstrate that HSI can measure tissue oxygenation with spatial resolutions of 100 microns without coming into contact with the patient's foot.
As reported previously [ 1- 3], there are several instruments commercially available which use different techniques to measure tissue oxygenation, e.g. in the brain.
A PeriFlux 5000 laser Doppler and transcutaneous oxygen meter (Perimed Inc., North Royalton, OH) was placed at seven spots along each skin flap to measure tissue oxygenation and perfusion levels at these positions.
Regional differences in brain perfusion, metabolism and oxygenation could be large among different brain areas in TBI patients, and PtiO2 monitoring as a regional technique only measures tissue oxygen pressure in a very small tissue volume.
In fact, our increased ability to assess tissue oxygenation clearly implies that measured plasma lactate concentration is only a small window of a much more complicated scenario.
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measuring tissue cortisol
measuring tissue myeloperoxidase
measuring tissue malondialdehyde
measuring tissue degradation
measuring tissue transglutaminase
measuring tissue enhancement
measuring tumour oxygenation
measuring tissue irritation
measuring wound oxygenation
measuring tissue hemoglobin
measuring tissue protein
measuring tissue capillary
measuring tissue oxygen
measuring tissue glycation
measuring tissue perfusion
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